Sofosbuvir*
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API Product :
Sofosbuvir*
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CEP :
-
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WCC :
?
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Therapeutic Use :
Antivirals for systemic use
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Originator :
GILEAD SCIENCES
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CAS No. :
1190307-88-0
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Trade Name. :
SOVALDI
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Molecular Weight :
529.453 g/mol
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Molecular Formula :
C22H29FN3O9P
Application
Sofosbuvir is used with other antiviral medications (such as ribavirin, peginterferon, daclatasvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. It works by reducing the amount of hepatitis C virus in your body, which may help your liver recover.
General Description
Sofosbuvir, sold under the brand name Sovaldi among others, is a medication used for the treatment of hepatitis C.[1] It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir, daclatasvir, or velpatasvir.[3][4] Cure rates are 30 to 97% depending on the type of hepatitis C virus involved.[5] Safety during pregnancy is unclear; some of the medications used in combination may result in harm to the baby.[5] It is taken by mouth.[1] Common side effects include feeling tired, headache, nausea, and trouble sleeping.[1] Side effects are generally more common in interferon-containing regimens.[6]:7 Sofosbuvir may reactivate hepatitis B in those who have been previously infected.[7] In combination with ledipasvir, daclatasvir or simeprevir it is not recommended with amiodarone due to the risk of an abnormally slow heartbeat.[6] Sofosbuvir is in the nucleotide analog family of medication and works by blocking the hepatitis C NS5B protein.