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Active Pharmaceutical Ingredients (APIs)
  • Vildagliptin*

    • API Product   :   

      Vildagliptin*

    • CEP   :   

      -

    • WCC   :   

    • Therapeutic Use    :   

      Drugs used in diabetes

    • Originator   :   

      Novartis

    • CAS No.    :   

      274901-16-5

    • Trade Name.   :   

      Galvus/vildagluse/Gliptus

    • Molecular Weight   :   

      303.399 g/mol

    • Molecular Formula   :   

      C17H25N3O2

    Application

    Vildagliptin (previously LAF237, trade names Galvus, Zomelis,) is an oral anti-hyperglycemic agent (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs.

    General Description

    Vildagliptin (previously LAF237, trade names Galvus, Zomelis,) is an oral anti-hyperglycemic agent (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin inhibits the inactivation of GLP-1[2][3] and GIP[3] by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the islets of Langerhans in the pancreas. Vildagliptin has been shown to reduce hyperglycemia in type 2 diabetes mellitus.

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