API Product   :    Dimethyl Fumarate*
CEP   :    ¤
WCC   :    ?
Therapeutic Use    :    Other CNS Drugs; Nonsteroidal products for inflammatory skin disorders; Immunostimulating Agents; Antineoplastics; All Other Therapeutic Products
Other CNS Drugs; Nonsteroidal products for inflammatory skin disorders; Immunostimulating Agents; Antineoplastics; All Other Therapeutic Products
Originator   :    BIOGEN IDEC
CAS No.    :    624-49-47
Trade Name.   :    TECFIDERA
Molecular Weight   :    144.13 g/ mol
144.13 g/ mol
Molecular Formula   :    C6H8O4
Dimethyl fumarate is used to treat relapsing forms of multiple sclerosis (MS).It helps decrease the number of episodes of worsening MS.
Dimethyl fumarate (DMF) is the methyl ester of fumaric acid and is named after the earth smoke plant (Fumaria officionalis). DMF combined with three other fumaric acid esters (FAEs) is solely licensed in Germany as an oral therapy for psoriasis (trade name Fumaderm®). Since 2013, it has been used to treat adults with relapsing multiple sclerosis (trade name Tecfidera®). In 2017, a new oral formulation of DMF (trade name Skilarence®) was approved by the European Medicines Agency (EMA) for use in Europe as a treatment for moderate-to-severe plaque psoriasis . DMF is thought to have immunomodulatory properties without causing significant immunosuppression.