Tacrolimus
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API Product :
Tacrolimus
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CEP :
-
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WCC :
?
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Therapeutic Use :
Nonsteroidal products for inflammatory skin disorders; Ophthalmologicals; Stomatologicals, Mouth Preparations, Medicinal Dentifrices Etc; Other CNS Drugs; Immunosuppressants; Other dermatological preparations; All Other Therapeutic Products; Anti-Inflammatory And Anti-Rheumatic Products
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Originator :
Astellas Pharma
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CAS No. :
104987-11-3
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Trade Name. :
PROGRAF
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Molecular Weight :
804.018 g/mol
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Molecular Formula :
C44H69NO12
Application
Tacrolimus ointment is used to treat the symptoms of eczema (atopic dermatitis; a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes) in patients who cannot use other medications for their condition or whose eczema has not responded to another medication.
General Description
Tacrolimus, also known as fujimycin or FK506, is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the body's learned (or adaptive) immune response. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura's disease, and the skin condition vitiligo.